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Been carrying a pistol since 1982 and have used many holsters. I ordered this holster for my S&W M&P 10mm. Although Don Hume doesn't specifically list a holster for the 10mm model, the .45 version works perfectly. The holster works with or without optics and is not only comfortable for a large handgun, it conceals very well. I've had the holster for several months and used it quite a bit and highly recommend it. The wait was worth it! In all the years of carrying, I have a box of holsters, some that don't measure up wind up in the box. The H726 is a quality holster that won't go in that box.